Solve a problem that hasn't been solved. Here are some Stanford level pieces of advice on great entrepreneurship:
Build something piece by piece from the ground up especially when a program isnt utilizing its full resources. Push forward when governments and other enterprises are sitting idle. Reason by analogy or first principles the basic axioms look at the fundamental truths. Like a scientist would.
An integrator would be mashing and smashing things together. When it does work great value and opportunity is created. Example put together a handbag and luxury and you get LV to the masses. The example from the Stanford professor in the video below talks about Chipotle making quick service or "fast casual dining" through a line up at Chipotle created by Steve Els in Colorado.
Look for things to combine. The internet and retail sites are doing this all the time and this was accelerated with the pandemic growing e-commerce businesses but create novelty and gain traction.
Curiousity unlocks the ability to unlock opportunity. Continue to ask questions, discover, and probe. If you have an expertise and think you know it all then you don't create new opportunities and you fall behind in a rapidly changing world. See what others don't see and have a vision that can bend in a way that wasn't bent before.
For more information see Amy Wilkinson, from Stanford Graduate School of Business. Parts of the above are from her video and commentary from Richart Ruddie: https://www.youtube.com/watch?v=68QW15sBdKQ